Book ID: CBB001251848

The Golgi Apparatus: The First 100 Years (2009)

unapi

Morré, D. James (Author)
Mollenhauer, Hilton H. (Author)


Springer


Publication Date: 2009
Physical Details: xiii + 307 pp.; ill.; bibl.; index
Language: English

The Golgi Apparatus traces the first 100 years of GA discovery from the first published accounts from Pavia, Italy, in 1898 to the Centenary Celebration in Pavia, Italy, in 1998 to our most recent discoveries. It summarizes the past 50 years beginning with the modern era of GA discovery initiated in 1954 and made possible by the advent of the electron microscope, methods of cell fractionation and biochemical analysis, leading up to the present era where focus has been on molecular biology. Emphasized are organization and function, the existence and importance of cisternal tubules, development of methods of GA isolation and subfractionation, biochemical analyses of highly purified GA fractions and comparison to equally highly purified reference fractions and their use in cell free systems analysis of membrane trafficking, the concept of GA function as part of an integrated system of internal endomembranes (the endomembrane system), evidence for differentiation of membranes across the stacks of GA cisternae, and flux of membrane constituents along the polarity gradient defined by membrane differentiation all culminating in the membrane maturation or flow differentiation model of GA function. More recent contributions to GA in cell growth (enlargement) and to cancer are summarized in final chapters

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Description From its discovery in 1898 to the centenniary celebration in 1998.


Reviewed By

Review Dröscher, Ariane (2012) Review of "The Golgi Apparatus: The First 100 Years". History and Philosophy of the Life Sciences (pp. 642-643). unapi

Citation URI
https://data.isiscb.org/isis/citation/CBB001251848/

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Authors & Contributors
Reynolds, Andrew S.
Fasolo, Aldo
Oxana Kosenko
Lovisolo, Davide
Carlos Ramírez
Double, Susan
Concepts
Cellular biology
Biology
Evolution
Microbiology
Medicine
Metaphors; analogies
Time Periods
20th century
19th century
21st century
20th century, early
18th century
Places
Italy
Germany
Naples (Italy)
Russia
France
Europe
Institutions
Kaiser-Wilhelm-Institut für Biologie, Berlin
University of Sydney
Stazione Zoologica di Napoli
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