O'Malley, Maureen A. (Author)
Soyer, Orkun S. (Author)
Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences
Volume: 43
Pages: 58--68
Edition Details: Part of a special section: “Data-Driven Research in the Biological and Biomedical Sciences”
Language: English
A common way to think about scientific practice involves classifying it as hypothesis- or data-driven. We argue that although such distinctions might illuminate scientific practice very generally, they are not sufficient to understand the day-to-day dynamics of scientific activity and the development of programmes of research. One aspect of everyday scientific practice that is beginning to gain more attention is integration. This paper outlines what is meant by this term and how it has been discussed from scientific and philosophical points of view. We focus on methodological, data and explanatory integration, and show how they are connected. Then, using some examples from molecular systems biology, we will show how integration works in a range of inquiries to generate surprising insights and even new fields of research. From these examples we try to gain a broader perspective on integration in relation to the contexts of inquiry in which it is implemented. In today's environment of data-intensive large-scale science, integration has become both a practical and normative requirement with corresponding implications for meta-methodological accounts of scientific practice. We conclude with a discussion of why an understanding of integration and its dynamics is useful for philosophy of science and scientific practice in general.
...MoreArticle Leonelli, S. (2012) Introduction: Making Sense of Data-Driven Research in the Biological and Biomedical Sciences. Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences (p. 1).
Similar Citations
Article
Calvert, Jane;
(2012)
Systems Biology, Synthetic Biology and Data-Driven Research: A Commentary on Krohs, Callebaut, and O'Malley and Soyer
(/isis/citation/CBB001221589/)
Article
Keating, Peter;
Cambrosio, Alberto;
(2012)
Too Many Numbers: Microarrays in Clinical Cancer Research
(/isis/citation/CBB001221585/)
Article
Leonelli, Sabina;
Ankeny, Rachel A.;
(2012)
Re-Thinking Organisms: The Impact of Databases on Model Organism Biology
(/isis/citation/CBB001221584/)
Article
Leonelli, S.;
(2012)
Introduction: Making Sense of Data-Driven Research in the Biological and Biomedical Sciences
(/isis/citation/CBB001221581/)
Article
Fridolin Gross;
Nina Kranke;
Robert Meunier;
(2019)
Pluralization Through Epistemic Competition: Scientific Change in Times of Data-Intensive Biology
(/isis/citation/CBB374064986/)
Article
Krohs, Ulrich;
(2012)
Convenience Experimentation
(/isis/citation/CBB001221586/)
Chapter
Leonelli, Sabina;
(2011)
Packaging Small Facts for Re-Use: Databases in Model Organism Biology
(/isis/citation/CBB001000235/)
Book
Sara Green;
(2016)
Philosophy of Systems Biology: Perspectives from Scientists and Philosophers
(/isis/citation/CBB545077792/)
Article
Miles MacLeod;
Nancy J. Nersessian;
(2015)
Modeling systems-level dynamics: Understanding without mechanistic explanation in integrative systems biology
(/isis/citation/CBB511081415/)
Article
Green, Sara;
Wolkenhauer, Olaf;
(2013)
Tracing Organizing Principles: Learning from the History of Systems Biology
(/isis/citation/CBB001420760/)
Article
Callebaut, Werner;
(2012)
Scientific Perspectivism: A Philosopher of Science's Response to the Challenge of Big Data Biology
(/isis/citation/CBB001221588/)
Article
García-Sancho, Miguel;
(2012)
From the Genetic to the Computer Program: The Historicity of “Data” and “Computation” in the Investigations on the Nematode Worm C. elegans (1963--1998)
(/isis/citation/CBB001221583/)
Book
Hallam Stevens;
Sarah S. Richardson;
(2015)
Postgenomics: Perspectives on Biology after the Genome
(/isis/citation/CBB862623870/)
Book
Ben Martynoga;
(2018)
Molecular Tinkering: The Edinburgh Scientists Who Changed the Face of Modern Biology
(/isis/citation/CBB777108676/)
Article
Tahani Nadim;
(2016)
Data Labours: How the Sequence Databases GenBank and EMBL-Bank Make Data
(/isis/citation/CBB311562850/)
Book
Stevens, Hallam;
(2013)
Life out of Sequence: A Data-Driven History of Bioinformatics
(/isis/citation/CBB001213157/)
Article
Wennerström, Frida;
Dubois, Anna;
(2004)
Organising Research Interaction: A Case Study of a Research Project in Bioinformatics
(/isis/citation/CBB000770379/)
Article
Strasser, Bruno J.;
(2010)
Collecting, Comparing, and Computing Sequences: The Making of Margaret O. Dayhoff's Atlas of Protein Sequence and Structure, 1954--1965
(/isis/citation/CBB001022392/)
Article
Huber, Lara;
(2011)
LONI & Co: Die epistemische Spezifität digitaler Wissensräume in der kognitiven Neurowissenschaft
(/isis/citation/CBB001220458/)
Article
Michael Fry;
(2020)
Ontologically Simple Theories Do Not Indicate the True Nature of Complex Biological Systems: Three Test Cases
(/isis/citation/CBB515852529/)
Be the first to comment!