This paper describes the introduction of antipsychotic drugs in the FRG in relation to a new definition of the term ',efficacy' It focuses on problems of the standardization of clinical trials in West German psychiatry during the 1950s and 1960s. In particular, the development of a diagnostic card for the evaluation of efficacy will be discussed as part of a new experimental system and regarding its role in constructing new knowledge on neuroleptic effects.
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