Book ID: CBB001213249

The Philadelphia Chromosome: A Mutant Gene and the Quest to Cure Cancer at the Genetic Level (2013)

unapi

Wapner, Jessica (Author)


The Experiment, LLC


Publication Date: 2013
Physical Details: xiii + 303 pp.; ill.
Language: English

This work discusses the history of a genetic mutation, discovered in 1959, that causes chronic myeloid leukemia, and traces the research and breakthroughs that led to the creation of a drug that makes this once-fatal illness now treatable. It focuses on what is widely viewed as the 'poster child' of rational drug development in the cancer research world. The history of the founding of a genetic mutant chromosome in the indication of Chronic myeloid leukemia disease, and the subsequent development of "Gleevec," is the keynote of this publication.

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Citation URI
https://data.isiscb.org/isis/citation/CBB001213249/

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Authors & Contributors
Richardson, Sarah S.
Santesmases, María Jesús
Becsei Kilborn, Eva
Bertolaso, Marta
Beyer, Ann
Boveri, Theodor
Journals
Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences
Dynamis: Acta Hispanica ad Medicinae Scientiarumque Historiam Illustrandam
Gesnerus
HOST: Journal of History of Science and Technology
International Studies in the Philosophy of Science
Journal of the History of Biology
Publishers
Yale University
Cold Spring Harbor Laboratory Press
Columbia University Press
Johns Hopkins University Press
Oxford University Press
Rowman & Littlefield
Concepts
Chromosomes
Medicine
Cancer; tumors
Medical genetics
Genes
Discovery in medicine
People
Boveri, Theodor
Delbrück, Max
Lewontin, Richard C.
Miller, Oscar R.
Rous, Fancis Peyton
Time Periods
20th century, late
20th century
21st century
20th century, early
Places
United States
Great Britain
France
Madrid (Spain)
Institutions
Human Genome Project
Rockefeller Institute for Medical Research
World Health Organization (WHO)
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