Book ID: CBB001213249

The Philadelphia Chromosome: A Mutant Gene and the Quest to Cure Cancer at the Genetic Level (2013)

unapi

Wapner, Jessica (Author)


The Experiment, LLC


Publication Date: 2013
Physical Details: xiii + 303 pp.; ill.
Language: English

This work discusses the history of a genetic mutation, discovered in 1959, that causes chronic myeloid leukemia, and traces the research and breakthroughs that led to the creation of a drug that makes this once-fatal illness now treatable. It focuses on what is widely viewed as the 'poster child' of rational drug development in the cancer research world. The history of the founding of a genetic mutant chromosome in the indication of Chronic myeloid leukemia disease, and the subsequent development of "Gleevec," is the keynote of this publication.

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Citation URI
https://data.isiscb.org/isis/citation/CBB001213249/

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Authors & Contributors
Dietmar Steverding
Weatherall, David
Timmermann, Carsten
Thagard, Paul R.
Santesmases, María Jesús
Ross, Malcom
Journals
Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences
Studies in History and Philosophy of Science
Social History of Medicine
Signs: Journal of Women in Culture and Society
Science
Naturwissenschaftliche Rundschau
Publishers
Springer
Rowman & Littlefield
Oxford University Press
Auckland University Press
Yale University
Concepts
Disease and diseases
Cancer; tumors
Medicine
Chromosomes
Genes
Medical genetics
People
Miller, Oscar R.
Lewontin, Richard C.
Delbrück, Max
Time Periods
20th century, late
21st century
20th century
Places
United States
New Zealand
Australia
Institutions
National Institute of Health (U.S.)
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