Article ID: CBB001024020

Extrapolation, Uncertainty Factors, and the Precautionary Principle (2011)

unapi

This essay examines the relationship between the precautionary principle and uncertainty factors used by toxicologists to estimate acceptable exposure levels for toxic chemicals from animal experiments. It shows that the adoption of uncertainty factors in the United States in the 1950s can be understood by reference to the precautionary principle, but not by cost-benefit analysis because of a lack of relevant quantitative data at that time. In addition, it argues that uncertainty factors continue to be relevant to efforts to implement the precautionary principle and that the precautionary principle should not be restricted to cases involving unquantifiable hazards.

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Description Examines toxicologists' efforts to estimate acceptable exposure levels for toxic chemicals from animal experiments in the 1950s.


Citation URI
https://data.isiscb.org/isis/citation/CBB001024020/

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Authors & Contributors
Henry, Marc
Leonie Dendler
Gaby-Fleur Böl
Tousignant, Noemi
Hideyuki Hirakawa
Esselborn, Stefan
Journals
Social Studies of Science
History and Technology
Substantia: An International Journal of the History of Chemistry
Atti e Memorie, Rivista di Storia della Farmacia
Social History of Medicine
Science, Technology and Human Values
Publishers
Wiley-VCH
Columbia University Press
Berghahn Books
University of California, Berkeley
Yale University
Harvard University
Concepts
Chemistry
Risk assessment
Risk
Biochemistry
Toxicology
Science and society
People
Guareschi, Icilio
Zhabotinskii, Anatol Markovich
Schoental, Regina
Gibson, Frank William Ernest
Belousov, Boris Pavlovich
Time Periods
20th century
21st century
19th century
20th century, late
20th century, early
Places
United States
Germany
Japan
Italy
France
Australia
Institutions
Brookhaven National Laboratory (United States)
Lawrence Berkeley Laboratory
United States. Food and Drug Administration (USFDA)
Toxicity Laboratory (University of Chicago)
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