Article ID: CBB001021932

Conrad Hal Waddington (1905--1975): el naixement de l'epigenètica (2009)

unapi

Waddington was an active investigator as an embryologist and genetist from the 1930s to 1950s. Over this period he did a brilliant work in theoretical biology developing concepts such as genetic assimilation and epigenetic landscape .Waddington's epigenetic landscape is a metaphor for how gene regulation modulates development. This idea was actually based on experiment: Waddington found that one effect of mutation was to affect how cells differentiated. In the studies of development,Waddington speculated on the meaning of the epigenetic landscape as reflected in his works Organisers and Genes (1940) and The strategy of the Genes (1957). Waddington describes epigenetics as the causal analysis of development, in other words, all those mechanisms (genetics and environmental) necessary to activate the genetic program of development.

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Authors & Contributors
Nicoglou, Antonine
Faillaci, Francesca
Chiapperino, Luca
Giuffrida, Pietro
Sideli, Lucia
Merlin, Francesca
Concepts
Genetics
Developmental biology
Epigenetics
Biology
Embryology
Mutation
Time Periods
20th century
21st century
19th century
20th century, early
Places
Great Britain
United States
Russia
Germany
Institutions
Columbia University (New York City)
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