The paper studies the great epidemics that have affected Europe from the middle ages until the 20th century. A special emphasis is put on in the mortality of the Black Death in 1348 (500 per thousand), the smallpox in the 18th century (150 per thousand), the spotted fever in the end of the 18th century (50 per thousand), the cholera pandemic in the 19th century (25.5 - 62.7 per thousand), the tuberculosis in the end of the 19th century (5.3 per thousand) and the mortality that the Spanish influenza produced in the beginnings of the 20th century (12.1 per thousand) in the Basque Country.
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