Article ID: CBB000932240

Directed Evolution: A Historical Exploration into an Evolutionary Experimental System of Nanobiotechnology, 1965--2006 (2008)

unapi

Abstract This study explores the history of nanotechnology from the perspective of protein engineering, which differs from the history of nanotechnology that has arisen from mechanical and materials engineering; it also demonstrates points of convergence between the two. Focusing on directed evolution---an experimental system of molecular biomimetics that mimics nature as an inspiration for material design---this study follows the emergence of an evolutionary experimental system from the 1960s to the present, by detailing the material culture, practices, and techniques involved. Directed evolution, as an aspect of nanobiotechnology, is also distinct from the dominant biotechnologies of the 20th century. The experimental systems of directed evolution produce new ways of thinking about molecular diversity that could affect concepts concerning both biology and life.

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https://data.isiscb.org/isis/citation/CBB000932240/

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Authors & Contributors
Blount, Zachary D.
Pandey, Poonam
Gisle Solbu
Bruchez, Marcel
Heidrun Åm
Yi, Doogab
Concepts
Molecular biology
Biotechnology
Microbiology
Nanotechnology
DNA; RNA
Biology
Time Periods
20th century, late
21st century
20th century
19th century
18th century
Places
United States
Norway
India
Great Britain
Institutions
Asilomar Conference on Recombinant DNA Molecules (1975)
Stanford University
Royal Society of London
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