Article ID: CBB000930718

“Zur Selbstreproduktion befähigter Substanzen” als zelluläre Angriffsorte chemischer Cancerogene (2007)

unapi

"Substances capable of self-reproduction as cellular targets of chemical carcinogens. In the course of studies on chemical carcinogenesis, which included animal experiments with a carcinogenic azo dye and a mathematical analysis of the observed effects, Hermann Druckrey and Karl Küpfmüller showed in 1948 that carcinogens induce heritable changes by targeting cellular substances capable of self-reproduction. The authors did not discuss the chemical nature of these substances which remained unclear for a long time thereafter. It was not until 1964 that deoxyribonucleic acid (DNA) was recognized, by Peter Brookes and Philip Lawley, as a target for the genotoxic action of chemical carcinogens. In retrospect, the results of Druckrey and Küpfmüller gave an early, indirect and until now not considered hint to an important role of DNA (the substance) malfunction in the development of cancer, since DNA is the only molecule capable of self-reproduction.The results are now appreciated in light of the scientific knowledge available at the time.

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Authors & Contributors
Witkowski, Jan A.
Armon, Rony
Assis, Leandro
Bächi, Beat
Barker, Crispin Robert Claude
Fisher, Susie
Journals
History and Philosophy of the Life Sciences
Journal of the History of Biology
Ambix: Journal of the Society for the History of Alchemy and Chemistry
Berichte zur Wissenschaftsgeschichte
Biology and Philosophy
British Journal for the History of Science
Publishers
Cold Spring Harbor Laboratory
Yale University
Brill
Cold Spring Harbor Laboratory Press
Concepts
Cancer; tumors
DNA; RNA
Biochemistry
Molecular biology
Genetics
Medicine
People
Temin, Howard M.
Berg, Paul
Cook, James Wilfred
Hennig, Willi
Miller, Elizabeth C.
Miller, James A.
Time Periods
20th century, late
20th century
21st century
19th century
20th century, early
Places
Germany
United States
Great Britain
Spain
Institutions
Atomic Bomb Casualty Commission
Stanford University
U.S. Atomic Energy Commission
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