Article ID: CBB000831432

Crick's Notion of Genetic Information and the “Central Dogma” of Molecular Biology (2007)

unapi

An assessment is offered of the recent debate on information in the philosophy of biology, and an analysis is provided of the notion of information as applied in scientific practice in molecular genetics. In particular, this paper deals with the dependence of basic generalizations of molecular biology, above all the `central dogma', on the socalled `informational talk' (Maynard Smith [2000a]). It is argued that talk of information in the `central dogma' can be reduced to causal claims. In that respect, the primary aim of the paper is to consider a solution to the major difficulty of the causal interpretation of genetic information: how to distinguish the privileged causal role assigned to nucleic acids, DNA in particular, in the processes of replication and protein production. A close reading is proposed of Francis H. C. Crick's On Protein Synthesis ([1958]) and related works, to which we owe the first explicit definition of information within the scientific practice of molecular biology.

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Description “A close reading is proposed of Francis H. C. Crick's “On Protein Synthesis” ([1958]) and related works, to which we owe the first explicit definition of information within the scientific practice of molecular biology.” (from the abstract)


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Authors & Contributors
Fabrizio Rufo
Witkowski, Jan A.
Williams, Gareth
Wilkins, Maurice
Schindler, Samuel
Ridley, Matt
Journals
Minerva: A Review of Science, Learning and Policy
British Journal for the Philosophy of Science
British Journal for the History of Science
Publishers
Pegasus Books
Donzelli
Atlas Books
Concepts
DNA; RNA
Molecular biology
Genetics
Microbiology
Biology
Protein synthesis
People
Crick, Francis
Watson, James Dewey
Perutz, Max Ferdinand
Bernal, John Desmond
Time Periods
20th century
20th century, late
21st century
19th century
20th century, early
Places
England
Great Britain
Institutions
Human Genome Project
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