In Renaissance and early modern times, the concept of imagination (Latin imaginatio) was essential for the (natural) philosophical explanation of magic processes, especially in the anthropology of Paracelsus. He assumed that imaginatio was a natural vital power including cosmic, mental, psychical, and physical dimensions. The Paracelsians criticized traditional humor pathology ignoring their theory of natural magic. On the other hand, they were criticized by their adversaries as charlatans practicing black magic. About 1800, in between enlightenment and romanticism, the healing concept of animal magnetism (Mesmerism) evoked an analogous debate, whether magnetic phenomena originated from a real (physical) power (so-called fluidum) or were just due to fantasy or imagination (German Einbildungskraft). At the end of the 19th century, the French internist Hippolyte Bernheim created - against the background of medical hypnosis (hypnotism) as a consequence of Mesmerism - his theory of suggestion and autosuggestion: a new paradigm of psychological respectively psychosomatic medicine, which became the basis for the concept of placebo in modern biomedicine. From now on, all the effects of alternative medicine could easily be explained by the placebo-effect, more or less founded - at least unconsciously - on fraud.
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