Holliday, Robin (Author)
The early years of molecular biology were characterized by a strong interaction between theory and experiment. This included the elucidation of the structure of DNA itself; genetic fine structure, recombination and repair; DNA replication; template-directed protein synthesis; the universality of the triplet genetic code, and the co-linearity of the DNA sequence of structural genes and the sequence of amino acids in proteins. The principle of co-linearity was later modified when split genes were discovered.. It is suggested that accurate splicing of gene transcripts might also be template directed. In 1958 Crick proposed a 'central dogma' of molecular biology stating that information could not be transmitted from proteins to DNA. Nevertheless, proteins can chemically modify DNA, and this is now known to have strong effects on gene expression.
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Book
Olby, Robert;
(2009)
Francis Crick: Hunter of Life's Secrets
(/isis/citation/CBB001021210/)
Book
Ridley, Matt;
(2006)
Francis Crick: Discoverer of the Genetic Code
(/isis/citation/CBB000641605/)
Article
Elkin, Lynne Osman;
(2003)
Rosalind Franklin and the Double Helix
(/isis/citation/CBB000340191/)
Book
Everson, Ted;
(2007)
The Gene: A Historical Perspective
(/isis/citation/CBB000700846/)
Article
Šustar, Predrag;
(2007)
Crick's Notion of Genetic Information and the “Central Dogma” of Molecular Biology
(/isis/citation/CBB000831432/)
Article
Argüelles, Juan Carlos;
(2007)
The Double Helix Revisited: A Paradox of Science and a Paradigm of Human Behaviour
(/isis/citation/CBB000831509/)
Article
Schindler, Samuel;
(2008)
Model, Theory, and Evidence in the Discovery of the DNA Structure
(/isis/citation/CBB001230045/)
Article
Bud, Robert;
(2013)
Life, DNA and the Model
(/isis/citation/CBB001252903/)
Book
Gareth Williams;
(2019)
Unraveling the Double Helix: The Lost Heroes of DNA
(/isis/citation/CBB941542186/)
Chapter
Rheinberger, Hans-Jörg;
(2012)
Internationalism and the History of Molecular Biology
(/isis/citation/CBB001422700/)
Essay Review
Strauss, Bernard S.;
(2004)
Rosy and Jim: The Mystery of the Double Helix
(/isis/citation/CBB001566358/)
Book
Bernardino Fantini;
Fabrizio Rufo;
(2017)
Il codice della vita. Una storia della genetica tra scienza e bioetica
(/isis/citation/CBB297801530/)
Article
Alexander von Schwerin;
(2015)
Shaping Vulnerable Bodies at the Thin Boundary between Environment and Organism: Skin, DNA Repair, and a Genealogy of DNA Care Strategies
(/isis/citation/CBB878598043/)
Book
Schwartz, James;
(2008)
In Pursuit of the Gene: From Darwin to DNA
(/isis/citation/CBB000774889/)
Article
Lazcano, Antonio;
(2012)
The Biochemical Roots of the RNA World: from Zymonucleic Acid to Ribozymes
(/isis/citation/CBB001251465/)
Article
Marcum, James A.;
(2002)
From Heresy to Dogma in Accounts of Opposition to Howard Temin's DNA Provirus Hypothesis
(/isis/citation/CBB000501150/)
Article
Gingras, Yves;
(2010)
Revisiting the “Quiet Debut” of the Double Helix: A Bibliometric and Methodological note on the “Impact” of Scientific Publications
(/isis/citation/CBB000933112/)
Article
de Chadarevian, Soraya;
(2003)
Relics, Replicas, and Commemorations
(/isis/citation/CBB000600547/)
Article
Morange, Michel;
(2008)
Fifty Years of Central Dogma
(/isis/citation/CBB001034015/)
Article
Sophie Juliane Veigl;
Oren Harman;
Ehud Lamm;
(2020)
Friedrich Miescher’s Discovery in the Historiography of Genetics: From Contamination to Confusion, from Nuclein to DNA
(/isis/citation/CBB137073400/)
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