Article ID: CBB000034505

From microsomes to ribosomes: “Strategies” of “representation” (1995)

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Description “I intend to exemplify these counterintuitive issues on `strategy' and `representation' in science by going into considerable detail about a research process that originated at the Rockefeller Institute for Medical Research. It started, in 1911, with Peyton Rous's tentative identification of a cancer-inducing agent as an ultramicroscopic organism. Through a series of unprecedented events made possible by the conjunction of different techniques of representation, including ultracentrifugation and electron microscopy, this agent was replaced by what for a long time was considered to be, and was structurally described as, a microsome. Through another shift, the microsomal pellet differentiated into a membrane part and a protein-synthesizing organelle, which came to be referred to as the ribosome by the late 1950s.”


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https://data.isiscb.org/isis/citation/CBB000034505/

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Authors & Contributors
Christopher W. McCracken
Derek Van Ittersum
Olivetti, Laura
Vray, Bernard
Verhave, Jan Peter
Tripoczky, Joachim
Concepts
Microbiology
Medicine
Public health
Bacteriology
Molecular biology
Biology
Time Periods
20th century
19th century
20th century, late
20th century, early
18th century
17th century
Places
United States
Mexico
Catalonia (Spain)
Russia
Italy
Institutions
Rockefeller Institute for Medical Research
International Biological Program
McCollum-Pratt Institute
Johns Hopkins University (Baltimore, Md.)
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